Non Animal Testing Database

COVID-19 can cause severe inflammation in the brain

University Medical Center Freiburg, Freiburg, Germany(1)
University of Freiburg, Freiburg, Germany(2)
The researchers interrogated the brain stem and olfactory bulb in brain samples of COVID-19 patients postmortem using imaging mass cytometry to understand the local immune response at a spatially resolved, high-dimensional single-cell level. They compared this immune map to non-COVID respiratory failure, multiple sclerosis and control patients. The findings show that a severe inflammatory response can develop in the central nervous system of COVID-19 patients involving different immune cells around the vascular system and in the brain tissue. This study identifies profound neuroinflammation with activation of innate and adaptive immune cells as correlates of COVID-19 neuropathology, with implications for potential therapeutic strategies.
Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T cell interactions
Bertram Bengsch(1), Marco Prinz(2)
Added on: 06-22-2021
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