"ID";"Original Title";"Title";"Summary";"Contact";"Citation";"URL Scientific Article";"More References";"Keywords";"Field of Research";"Method/Model";"Year of Publication";"Month of Publication";"Date of Editing"; "601";"Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T cell interactions";"COVID-19 can cause severe inflammation in the brain";"The researchers interrogated the brain stem and olfactory bulb in brain samples of COVID-19 patients postmortem using imaging mass cytometry to understand the local immune response at a spatially resolved, high-dimensional single-cell level. They compared this immune map to non-COVID respiratory failure, multiple sclerosis and control patients. The findings show that a severe inflammatory response can develop in the central nervous system of COVID-19 patients involving different immune cells around the vascular system and in the brain tissue. This study identifies profound neuroinflammation with activation of innate and adaptive immune cells as correlates of COVID-19 neuropathology, with implications for potential therapeutic strategies.";"Marco Prinz, University of Freiburg, Freiburg, Germany, Bertram Bengsch, University Medical Center Freiburg, Freiburg, Germany";"Marius Schwabenland et al. Immunity 2021";"https://www.sciencedirect.com/science/article/pii/S1074761321002466";"Bionity, https://www.bionity.com/en/news/1171484/covid-19-can-cause-severe-inflammation-in-the-brain.html";"neuropathology, COVID-19, imaging methods, cell analysis";"Microbiology, Infectiology, Neurology";"Human studies, Epidemiology, Cell culture, Tissue models";"2021";"06";"2021-06-22 14:55:03";