Microfluidic organ-on-chip device to assess anti-tumor drug response
December 2018
Paris Sciences et Lettres Research University, Paris, France
The tumor microenvironment has been shown to have a key role in cancer progression. Lately, in vitro organ-on-chip technologies have been gaining popularity to integrate multicellular models that allow to better recapitulate the in vivo conditions. Here, a 3D co-culture microfluidic device based on organ-on-chip methods is used to culture ex vivo HER2+ human breast cancer samples together with other cell types commonly present in the in vivo environment. The results show that treating with trastuzumab replicated the anti-tumoral antibody-dependent cell-mediated toxicity immune response. However, cancer-associated fibroblasts were able to antagonize the effects of the drug. Altogether, the researchers present a new model that can be used to study ex vivo the drug response in an immunocompetent tumor microenvironment to assess the potential drug response of certain therapeutic strategies.
Dissecting effects of anti-cancer drugs and cancer-associated fibroblasts by on-chip reconstitution of immunocompetent tumor microenvironments
Maria Carla Parrini
Added on: 10-05-2021
[1] https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31926-0[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
