Ex vivo enrichment of anti-cancer immune cells from donors
2017
Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
Adoptive immunotherapy using cytokine-induced killer cells (CIK) have been used in the clinic for a variety of malignant tumors. However, the preparation of CIK cells is heterogeneous and this affects the therapeutic efficacy. In the present study, the researchers report the enrichment and expansion of a particular subset of CIK cells from donors. The cells were characterized using flow cytometry and their cytotoxic potential was assessed in vitro against cancer cell lines. Sequencing analysis determined a preference of the CIK for a particular receptor present in ovarian cancer cells. The results suggest that transplantation of ex vivo enriched and expanded CIK cells may provide a novel avenue of targeted therapy for ovarian cancer.
Phenotypic characterization and anticancer capacity of CD8+ cytokine-induced killer cells after antigen-induced expansion
Yilin Cao, Wenjie Zhang
Added on: 09-18-2021
[1] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0175704[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
