Development of a web-based platform to help designing immunotherapy against cancer
November 2016
CSIR-Institute of Microbial Technology, Chandigarh, India
Identification of cancer-specific epitopes or neoepitopes from cancer genomes is one of the major challenges in the field of immunotherapy or vaccine development. Due to advancements in sequencing technology, the genomes of thousands of cancer tissues or cell lines have been sequenced. In the present study, the researchers developed an in silico platform (called Cancertope) for designing genome-based immunotherapy or vaccine against cancer cells. To do this, the researchers analyzed the mutational profile of 905-cancer cell lines and identified neoepitopes that can activate different arms of the immune system. The platform can be used to look for cancer antigens but can also be used in a personalized fashion to identify neoepitopes from the genomes of cancer patients. Cancertope is a web-based platform open for use by the scientific community.
A platform for designing genome-based personalized immunotherapy or vaccine against cancer
Gajendra P. S. Raghava
Added on: 09-17-2021
[1] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166372[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
