Relation between obesity, inflammation and severity of prostate cancer tested in patients' tissue
2016
Thomas Jefferson University, Philadelphia, USA
Obesity is a potentially modifiable risk factor for disease progression and poor outcomes for numerous diseases, including prostate cancer (PCa). One possible link in the relationship between obesity and PCa progression is inflammation. Obesity produces a state of systemic chronic low-grade inflammation that can contribute to a number of chronic diseases, including advanced PCa. In the present study, the researchers aimed at examining prostatic inflammation via tumor-infiltrating lymphocytes and macrophages characterized by obesity and cancer severity.
Prostate tissue from 99 participants (63 non-obese and 36 obese) were analyzed for type and count of lymphocytes and macrophages and the pathology data were linked to clinical and demographic variables. The results showed that the number of lymphocytes and macrophages in the tumor microenvironment did not differ by obesity status. However, these inflammation markers were associated with poor prostate cancer outcomes. Further examination of underlying mechanisms that influence obesity-related effects on prostate cancer outcomes is still needed to guide immunotherapy protocols and weight management as they apply to diverse patient populations and phenotypes.
The relationship between obesity, prostate tumor infiltrating lymphocytes and macrophages, and biochemical failure
Charnita Zeigler-Johnson
Added on: 09-17-2021
[1] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0159109[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
