New potential target for immunotherapy discovered from lung cancer patients' tissues
2014
University of Florida, Gainesville, USA
Initiation and progression of lung cancer mainly relies on the tumor microenvironment. Interaction between cancer cells and part of the immune system has been shown to facilitate cancer cell invasion and metastasis, although the molecular mechanisms at play are poorly understood. In the present study, the researchers aimed at analysing if the presence of one particular receptor called Triggering receptor expressed on myeloid cells 1 (TREM-1) could be a predictor of lung cancer patients prognosis. Using tumor tissue from patients, the researchers showed an increased expression of TREM-1. Immunohistochemistry and immunofluorescence on the patients' tissues showed that the expression of TREM-1 was selectively seen in a particular type of macrophage. The data was confirmed in vitro when co-culturing macrophages with cancer cells. The study proposes that TREM-1 might be a novel target for tumor immunomodulation.
TREM-1 is induced in tumor associated macrophages by Cyclo-Oxygenase pathway in human Non-Small Cell Lung Cancer
Ruxana T. Sadikot
Added on: 09-17-2021
[1] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094241[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
