Immune response analysis in gastric cancer patient's tissues
December 2017
The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
Gastric cancer (GC) is one of the leading causes of mortality worldwide. Investigations showed that T-cell dysfunction is crucial to understand human tumor growth. Currently, there is little detail of T-cell subsets resident within gastric cancer tissues or the expression patterns in this microenvironment. In the present study, the researchers investigated the distribution of T-cells subset, the differentiation and inhibitory phenotype of T-cells from blood and tissues of GC patients. Phenotypic analysis was based on the isolation of tumor-infiltrating lymphocytes. The study characterizes a specific T-cell subsets resident within GC whose behaviour could be corrected to tumor infiltration using blockade inhibitor. The study underlines the need for a holistic view of immune response in cancer to design proper therapy.
Tumor-infiltrating CD4+ T cells in patients with gastric cancer
Quanli Gao
Added on: 09-15-2021
[1] https://cancerci.biomedcentral.com/articles/10.1186/s12935-017-0489-4[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
