Oral cancer patients' tissue analysis to understand immune response
2015
Meikai University of School of Dentistry, Saitama, Japan
Oral leukoplakia is a premalignant lesion of the oral mucosa, it has been shown that a subtype of patients has an increased risk for malignant transformation. Numerous studies have shown the role of tumor-associated macrophages (TAMs) to potentially initiate and promote tumorigenesis and a correlation with an abundance of TAMs and poor prognosis for many cancer patients although the claim was contradicted in other cancers. In the present study, the researchers aimed at identifying the phenotype of TAMs in leukoplakia. Tissues were isolated from patients and analyzed by immunohistochemistry. The study shows an increase in the rate TAM infiltration was observed in mild and moderate leukoplakia which positively correlated with the expression of two markers specific for macrophages with the capacity to disrupt tissue architecture. Hence, the study sheds more light on the cascade of immunological events leading to malignant transformation.
Tumor-associated macrophages in oral premalignant lesions coexpress CD163 and STAT1 in a Th1-dominated microenvironment
Yoshihiro Ohmori
Added on: 09-15-2021
[1] https://bmccancer.biomedcentral.com/articles/10.1186/s12885-015-1587-0[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
