In vitro knockdown of cancer marker shows promises for therapy development
2015
Sichuan University, Chengdu, China
Lung cancer is the leading cause of cancer-related mortality with high incidence rates, metastatic propensity, and acquired resistance to therapy. Many studies have shown that the pituitary tumor-transforming gene (PTTG) is an oncogene that is overexpressed in a variety of tumors, however other studies suggest a negative correlation. In this study, the researchers aimed at clarifying if PTTG could be a marker for prognosis in lung adenocarcinoma cells. PTTG expression levels were assessed in human LAC tissues by an immunohistochemical assay using a tissue microarray procedure. Further, in vitro loss-of-function experiments were conducted to investigate the effects of PTTG on cell growth and invasive potential in LAC cell lines. Overall, PTTG1 protein expression was upregulated in LAC tissues and was positively associated with the lymphatic invasion of the tumor. The knockdown of PTTG expression inhibited tumor proliferation and invasion of LAC cells. The present findings suggest that PTTG may be a potential target for developing an effective immunotherapeutic strategy for LAC.
Knockdown of PTTG1 inhibits the growth and invasion of lung adenocarcinoma cells through regulation of TGFB1/SMAD3 signaling
Zheng-Rong Wang
Added on: 09-14-2021
[1] https://journals.sagepub.com/doi/10.1177/0306419015572073[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
