Modified mesenchymal stem cells for Parkinson's cell therapy
2014
The 148th Hospital, Zibo, China
Parkinson's disease is a devastating neurodegenerative disorder that is characterized by a massive loss of dopaminergic neurons. Despite having a lot of attention, there is still no effective cure for it. Cell therapy has been growing in the last years as a feasible option for Parkinson's treatment and mesenchymal stem cells derived from human umbilical cord are gaining popularity. Here, human umbilical cord mesenchymal stem cells overexpressing HGF, a neuroprotective factor, have been used to treat neuroblastoma cells in a Parkinson's model based on MPP+ treatment. The results show that the supernatant from HGF overexpressing cells promoted the regeneration of neuroblastoma cells at higher efficacy than those that did not overexpress HGF. Additionally, the researchers decipher some mechanistic hints of this effect that point to the modulation of calcium signalling. In this study, a new potential approach is developed for the regeneration of damaged neurons in Parkinson's disease.
Human umbilical cord mesenchymal stem cells Infected with adenovirus expressing HGF promote regeneration of damaged neuron cells in a Parkinson’s disease model
Yun-Liang Wang, Bing Han
Added on: 08-31-2021
[1] https://www.hindawi.com/journals/bmri/2014/909657/[2] https://data.jrc.ec.europa.eu/dataset/a8fd26ef-b113-47ab-92ba-fd2be449c7eb
