Dopaminergic neurons from multipotent stem cells
October 2013
Second Military Medical University, Shanghai, China
Human bone marrow multipotent stem cells have been used in the last decades as a source of cell material for cell therapy strategies. Mainly, the applications have been directed towards regeneration strategies of bone tissue, cartilages, or hepatic tissue. However, little is known about the potential of these multipotent stem cells to be used in neural regeneration. Here, aged human bone marrow multipotent stem cells were used to generate dopaminergic neurons that could be potentially used in Parkinson's disease therapies. The results show that these cells could be maintained in vitro for a long time, keeping the expression of pluripotent genes and could generate cells from the three germ layers. When induced with specific factors, it was possible to generate cultures with up to 70% of dopaminergic neurons that could secrete dopamine upon depolarization. In this study, the researchers propose a new source of cell material to develop autologous cell replacement strategies for Parkinson's disease, even from aged patients.
Directed differentiation of aged human bone marrow multipotent stem cells effectively generates dopamine neurons
Houqi Liu
Added on: 08-31-2021
[1] https://link.springer.com/article/10.1007%2Fs11626-013-9701-6[2] https://data.jrc.ec.europa.eu/dataset/a8fd26ef-b113-47ab-92ba-fd2be449c7eb
