Regeneration of neural cells with cell therapy in vitro
2017
Academy of Military Medical Sciences, Beijing, China(1)
Chinese PLA General Hospital and Chinese PLA Medical School, Beijing, China(2)
Chinese PLA General Hospital and Chinese PLA Medical School, Beijing, China(2)
Alzheimer's disease is the most prevalent dementia and one of the most known neurodegenerative diseases. So far, there is no effective cure to stop or reverse it. Several types of therapeutic strategies based on the use of stem cells have been investigated. Here, human dental pulp stem cells are used to reverse the degeneration of okadaic-induced damage on human neuroblastoma cells. This model reproduces the retraction of dendrites and increase of cytotoxicity seen in neurodegeneration, which is counteracted by co-culture with human dental pulp stem cells. Several assays of this model confirmed that these stem cells not only stop neurotoxicity but are able to restore the normal morphology of neural cells. Additionally, it was possible to significantly reduce the phosphorylation of tau protein after treatment. These results show the potential of human dental pulp stem cells to induce regeneration of neural cells in the context of neurodegeneration and opens the road for further studies in this direction.
Dental pulp stem cells promote regeneration of damaged neuron cells on the cellular model of Alzheimer's disease
Xuetao Pei(1), Huixia He(2)
Added on: 08-17-2021
[1] https://onlinelibrary.wiley.com/doi/10.1002/cbin.10767[2] https://data.jrc.ec.europa.eu/dataset/a8fd26ef-b113-47ab-92ba-fd2be449c7eb
