Anti-inflammatory effects of memantine in vasuclar endothelial cells
2017
The First Affiliated Hospital of Kunming Medical University, Kunming, China
In recent years, vascular endothelium dysregulation has been related to Alzheimer's disease. Memantine is an approved drug used to treat Alzheimer's disease, but little is known about its anti-inflammatory effects on the vascular endothelium. Here, a model based on primary human brain microvascular endothelial cells triggered with tumor necrosis factor-alpha is used to study the effects of memantine on endothelial inflammation. First, memantine prevented the attachment of human monocytes to endothelial cells. Afterwards, in an insert-based blood-brain barrier model, memantine preserved the integrity of the model and inhibited monocyte transmigration through the endothelial layer. The results show that memantine was able to prevent the expression of tumor necrosis factor-alpha triggered factors by inducing the inhibition of factor NF-kB. This study deciphers the anti-inflammatory mechanisms of memantine in endothelial cells and describes an "in vitro" model of the blood-brain barrier that can be potentially used to design new therapeutical strategies for neurological disorders.
Regulation of human brain microvascular endothelial cell adhesion and barrier functions by memantine
Fei Wang
Added on: 08-16-2021
[1] https://link.springer.com/article/10.1007/s12031-017-0917-x[2] https://data.jrc.ec.europa.eu/dataset/a8fd26ef-b113-47ab-92ba-fd2be449c7eb
