Drug testing on a new microchip-based model
2017
Ege University, Izmir, Turkey
The goal of this study is to test the response of human breast cancer cells and healthy mammary epithelial cells to carnosic acid and doxorubicin in a microchip model. Three models are compared: 2D monolayer culture, 3D culture and the microchip culture. It was found that cell viability was higher in the microchip model. Also, both therapeutic molecules had specific responses to different cancer cell lines and those responses were dependent on their chemical structure. Overall, this model shows to be a promising tool in the study of cancer therapeutics and allows the inclusion of structural complexity parameters into "in vitro" modelling.
Cytotoxic responses of carnosic acid and doxorubicin on breast cancer cells in butterfly-shaped microchips in comparison to 2D and 3D culture
Ozlem Yesil-Celiktas
Added on: 08-02-2021
[1] https://link.springer.com/article/10.1007/s10616-016-0062-3[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
