3D multicellular microfluidic system to study tumor microenvironment
2015
Seoul National University Hospital, Seoul, South Korea(1)
University of Pennsylvania, Philadelphia, USA(2)
University of Pennsylvania, Philadelphia, USA(2)
A new model based on a compartmentalized 3D microfluidic device is developed to mimic cancer tissue microarchitecture. By combining human breast tumor spheroids with human mammary gland epithelial cells and breast fibroblasts, the microenvironment of mammary gland carcinoma could be mimicked. Using this platform, the anticancer drug paclitaxel was tested in a highly complex "in vitro" model and the anticancer effects observed "in vivo" could be reproduced. Thus, this new platform can be a very useful tool to study the tumor microenvironment and to explore potential therapeutic agents.
A microengineered pathophysiological model of early-stage breast cancer
Woo Kyung Moon(1), Dongeun Huh(2)
Added on: 08-02-2021
[1] https://pubs.rsc.org/en/content/articlelanding/2015/lc/c5lc00514k[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
