Tunable hydrogels to study cell invasion
November 2015
University of Toronto, Toronto, Canada
The study describes the development of tunable hydrogels whose mechanical and chemical properties are modified to study the cell invasion mechanisms of human cancer cell lines. The results show that the presence of matrix metalloproteinases cleavable peptides increases cell invasion. These extracellular matrix mimetic hydrogels show that by tuning the microenvironmental properties it is possible to recapitulate variable tissue properties to study cell invasion.
Tuning the microenvironment: click-crosslinked hyaluronic acid-based hydrogels provide a platform for studying breast cancer cell invasion
Molly S Shoichet
Added on: 07-31-2021
[1] https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201502778[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
