Novel microfluidic 3D model to study metastasis mechanisms
2017
Chinese Academy of Sciences, Beijing, China(1)
Chongqing University, Chongqing, China(2)
Chongqing University, Chongqing, China(2)
The study describes the development of a new multicellular hydrogel-based microfluidic 3D model seeded with human breast epithelial cells and human breast cancer cells. When seeding the epithelial cells with human breast cancer cells, their normal self-organization was impeded. This model brings new insights into the possible mechanisms of disruption of luminal structures. It also has the potential to be used in high-throughput applications to study complex multicellular interactions in the tumor microenvironment.
A novel 3-D bio-microfluidic system mimicking in vivo heterogeneous tumour microstructures reveals complex tumour–stroma interactions
Zhongcan Ouyang(1), Fangfu Ye(1), Liyu Liu(2)
Added on: 07-29-2021
[1] https://pubs.rsc.org/en/content/articlelanding/2017/lc/c7lc00191f[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
