Human neuromuscular junction (NMJ) two-organ model for evaluation of therapeutics
Company 2018
Hesperos Inc., Orlando, USA
A 2-organ-on-a chip system was developed in which human myotubes and motoneurons derived from stem cells were cultured in a serum-free medium. The system is composed of two chambers linked by microchannels to enable axonal outgrowth to the muscle chamber that allows separate stimulation of each component and physiological neuromuscular junction (NMJ) function. Three dose-response curves were generated to demonstrate the pharmacological relevance of the system. This quantifiable functional human NMJ system establishes a platform for generating patient-specific NMJ models by including patient-derived iPSCs.
Stem cell derived phenotypic human neuromuscular junction model for dose response evaluation of therapeutics
James J. Hickman
Added on: 05-25-2020
[1] https://www.sciencedirect.com/science/article/pii/S0142961218301479?via%3Dihub[2] https://hesperosinc.com/technology/
