In vitro molecular characterization of immune response following infection with a potentially oncolytic virus
2018
Duke University School of Medicine, Durham, USA
Engaging innate antiviral responses is considered key for instigating tumor-antigen-specific antitumor immunity with cancer immunotherapy approaches. The recombinant poliovirus PVSRIPO could be potentially used as cancer therapy. In the present study, the researchers assessed the interaction of PVSRIPO and the innate antiviral response by infecting a panel of human melanoma cell lines and assaying in vitro innate immune signals and viral translation, propagation, and cytotoxicity over time. The results show that provoking an antiviral response in infected tumor cells without abrogating viral cytotoxicity and the presentation of endogenous tumor antigens may be particularly auspicious for PVSRIPO’s capacity for instigating tumor antigen-specific antitumor immunity.
Engineered oncolytic poliovirus PVSRIPO subverts MDA5- dependent innate immune responses in cancer cells
Matthias Gromeier
Added on: 07-29-2021
[1] https://journals.asm.org/doi/full/10.1128/JVI.00879-18[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
