Testing the capacity of oncolytic virus to treat brain cancers in patients tissue
2018
Duke University Medical Center, Durham, USA
Pediatric brain tumors could potentially be treated by poliovirus oncolytic immunotherapy. In the present study, the researchers analysed low-grade and malignant pediatric brain tumors infected with recombinant polio: rhinovirus (PVSRIPO) and determined the expression of the poliovirus receptor as proof of infection and propagation. Also, the capacity of the infection to lower cancer cell proliferation was shown in vitro. Given a similar successful translation of PVSRIPO to treat malignant gliomas in adult and pediatric patients, future work and prospective clinical trials should explore this possibility of PVSRIPO as an immunotherapeutic approach to treating pediatric brain tumors.
Poliovirus receptor (CD155) expression in pediatric brain tumors mediates oncolysis of medulloblastoma and pleomorphic xanthoastrocytoma
Eric M. Thompson
Added on: 07-29-2021
[1] https://academic.oup.com/jnen/article/77/8/696/5033817?login=true[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
