Hydrogel-based 3D model of breast cancer
2015
Brown University, Providence, USA
A hydrogel-based 3D model with human breast cancer cells is used to try to reproduce human breast tumour self-organisation and differentiation in different microtissues. When compared to a 2D model, this new model shows differential expression of different microtissue markers, which remain responsive to estrogen when exposed to 17β-estradiol. This study describes a 3D model that is more physiological than 2D models to study human breast cancer.
MCF-7 human breast cancer cells form differentiated microtissues in scaffold-free hydrogels
Kim Boekelheide
Added on: 07-29-2021
[1] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135426[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
