In vitro testing of antibody-drug conjugate in human cell lines
Company 2019
Catalent Biologics, Emeryville, USA
Immune checkpoint inhibitors in combination with chemotherapeutic drugs have been very promising yet these agents are systemically delivered and cytotoxic to all proliferating cells. Conjugating drugs with specific antibodies might induce immunogenic cell death in targeted cancer cells. In the present study, the researchers examined the response to antibody-drug conjugate treatment in human cell lines by using a set of in vitro markers. The results indicated that antibody-drug conjugates can selectively elicit hallmarks of immunogenic cell death on target antigen-expressing cells but not antigen-negative cells.
Maytansine-bearing antibody-drug conjugates induce in vitro hallmarks of immunogenic cell death selectively in antigen-positive target cells
David Rabuka
Added on: 07-29-2021
[1] https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1565859[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
