Ex vivo testing of the role of lymphatic vessel density in immune response in cancer patients tissues
2018
Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland(1)
University of Lausanne (UNIL), Lausanne, Switzerland(2)
University of Lausanne (UNIL), Lausanne, Switzerland(2)
Poor patient survival in melanoma and other cancers correlates with increased density of tumor-associated lymphatic vessels. Still, lymphatic drainage is essential for initiating an immune response. In the present study, the researchers assessed whether and how lymphatic vessel density (LVD) correlates with immune cell infiltration in primary tumors and lymph nodes from patients with cutaneous melanoma. The researchers used immunohistochemistry and quantitative image analysis on patients tissues and found significant positive correlations between LVD and immune cell infiltration as well as expression of the immunosuppressive molecules. Interestingly, similar associations were seen in tumor-free LNs adjacent to metastatic ones, indicating regional effects of tumors. The results suggest that lymphatic vessels play multiple roles at tumor sites.
Lymphatic vessel density is associated with CD8+ T cell infiltration and immunosuppressive factors in human melanoma
Melody A. Swartz(1), Daniel E. Speiser(2)
Added on: 07-29-2021
[1] https://www.tandfonline.com/doi/full/10.1080/2162402X.2018.1462878[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
