In vitro testing of increase of antigen presentation in cancer cells following chemotherapy
2018
University of London, London, United Kingdom
The success of immunotherapies depends on the antigenic makeup of tumour cells. Improving the efficacy of cancer treatments is to augment the antigens displayed by tumours. In the present study, the researchers explored possible alteration of tumour recognition by gemcitabine (GEM), a nucleoside analogue that has a broad spectrum of anti-tumour activity. Testing a panel of chemotherapeutics in human cancer cell lines in vitro, the researchers found that it was found that GEM increased surface expression of a variety of immunogenic antigens. These data may advise as to which antigens should be used in future vaccination protocols and reinforce the idea that chemotherapy and immunotherapy could be used in combination.
Gemcitabine alters the proteasome composition and immunopeptidome of tumour cells
A. M. Gravett
Added on: 07-29-2021
[1] https://www.tandfonline.com/doi/full/10.1080/2162402X.2018.1438107[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
