In vitro model of muscle cancer used to study immune response following treatment
2017
CNB-CSIC, Madrid, Spain
Bacillus Calmette-Guerin (BCG) is well known to be a potent enhancer of the immune response and as such has been used as a therapy for patients with high-risk non-muscle-invasive bladder cancer. However, the detailed mechanisms of action of this therapy are not well understood. In the present study, the researchers generated an in vitro model of human peripheral blood mononuclear cells (PBMCs) co-cultured with BCG to study the immune response. Natural Killer (NK) cells were especially present and active and this in vitro data was then confirmed in tissues from patients treated with BCG and not with another type of treatment. These observations suggest that activation of NK cells may be an important component of the anti-tumor immune response triggered by BCG therapy in bladder cancer.
Characterization of a human anti-tumoral NK cell population expanded after BCG treatment of leukocytes
Mar Valés-Gómez
Added on: 07-29-2021
[1] https://www.tandfonline.com/doi/full/10.1080/2162402X.2017.1293212[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
