Importance of tumor microenvironment for immune response against cancer shown in patients tissues
November 2016
University of Otago, Dunedin, New Zealand
The growth and spread of colorectal cancer (CRC) can be prevented partially by T cells but tumor microenvironment may pose difficulties. In this study, the researchers aimed at determining if T cells functionality was different in tumor or non-tumor tissues of patients. Tissues were obtained from a large cohort of patients and were then analysed ex vivo. T cell populations were at different frequencies and different subtypes between tumor and non-tumor of the same patients. Further, the T cells infiltrating the tumor have an impaired proliferative ability compared non-tumor environment. The study confirms the TME is crucial to predict the effect of immune-modulatory therapies.
Functional impairment of infiltrating T cells in human colorectal cancer
Roslyn A. Kemp
Added on: 07-29-2021
[1] https://www.tandfonline.com/doi/full/10.1080/2162402X.2016.1234573[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
