Study of immune response in a large cohort of breast cancer patients
2019
Zealand University Hospital, Slagelse, Denmark
Patients with a BRCA1 or BRCA2 mutation (BRCA-mutated breast cancer) are frequently diagnosed with low differentiated and highly proliferating breast cancer characterized by high amounts of tumor-infiltrating lymphocytes (Tils). Yet, the prognostic importance of Stromal Tils (sTils) in BRCA-mutated breast cancers is unknown. In this study, the researchers investigated sTils in a nationwide Danish cohort of BRCA1/2 carriers with primary breast cancer in terms of prevalence in sTils groups correlated with survival. STils were quantified on fixed tumor tissues from the patients. Breast cancer patients with a germline BRCA mutation had higher sTils than previously reported in sporadic breast cancers, and sTils were associated with favourable survival among BRCA carriers. In conclusion, BRCA breast cancers show high activation of the immune system and an increasing amount of sTils are associated with lower mortality.
Evaluation of tumor-infiltrating lymphocytes and association with prognosis in BRCA-mutated breast cancer
I.M.H. Sønderstrup
Added on: 07-28-2021
[1] https://www.tandfonline.com/doi/full/10.1080/0284186X.2018.1539239[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
