Assessing immune genes modifications in colorectal cancer patients
2014
St. George’s Hospital, London, United Kingdom
Patients with colorectal cancer (CRC) experience decreased immune function directly due to the development of the disease. In the present study, the researchers assessed the expression level of immune function genes. The researchers directly measured the expression level of those genes in CRC patients cells and also checked the epigenetic modification of these genes. Survival analysis of these patients was also performed to correlate survival rate with the gene expression and epigenetic modifications. The study shows specific alterations that may offer novel immunomodulatory approaches in the management of CRC.
Expression and DNA methylation of TNF, IFNG and FOXP3 in colorectal cancer and their prognostic significance
D. Kumar
Added on: 07-27-2021
[1] https://www.nature.com/articles/bjc2014477[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
