Tumor slice culture for drug validation
2016
Erasmus University Medical Center, Rotterdam, Netherlands
In the present study, a new method for culturing of human breast cancer tumor samples is developed. Several culture parameters are optimized to define specific conditions to grow tumor slices for a minimum of 7 days. Additionally, another method is developed to screen the cytotoxicity of the chemotherapeutic treatment FAC (5-FU, Adriamycin and Cyclophosphamide). The results show that this new platform is able to correctly predict resistant tumors from others, confirming the model's potential to improve personalized breast cancer treatment.
Tumor slice culture system to assess drug response of primary breast cancer
Dik C van Gent
Added on: 07-27-2021
[1] https://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2119-2[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
