Stromal-epithelial interactions in a 3D model of breast cancer
October 2015
University of North Carolina at Chapel Hill, Chapel Hill, USA
A multicellular organoid 3D system using human breast cancer cells and human fibroblast is used to study cell motility patterns with optical coherence tomography. The results show that the density of stromal cells affects several parameters of mammary cell motion and how to visualise hyperspectral data to observe heterogeneity within organoids. Overall, this study presents a new tool to image cellular functional changes with optical coherence tomography.
Inverse-power-law behavior of cellular motility reveals stromal–epithelial cell interactions in 3D co-culture by OCT fluctuation spectroscopy
Amy L Oldenburg
Added on: 07-27-2021
[1] https://www.osapublishing.org/optica/fulltext.cfm?uri=optica-2-10-877&id=330140[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
