3D bioprinted metastatic tumor microenvironment models
2019
Department of Mechanical Engineering, University of Minnesota, Minneapolis, USA
Vascularized tumor models are created via 3D bioprinting techniques to mimic key steps of cancer dissemination (invasion, intravasation, and angiogenesis), based on guided migration of tumor cells and endothelial cells in the context of stromal cells and growth factors. The utility of the metastatic models for drug screening is demonstrated by evaluating the anticancer efficacy of immunotoxins. These 3D vascularized tumor tissues provide a proof-of-concept platform to i) fundamentally explore the molecular mechanisms of tumor progression and metastasis, and ii) preclinically identify therapeutic agents and screen anticancer drugs.
3D bioprinted in vitro metastatic models via reconstruction of tumor microenvironments
Michael C. McAlpine
Added on: 05-25-2020
[1] https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201806899
