Colorectal cancer immune profiling in Lynch syndrome patients
2018
University of Texas MD Anderson Cancer Center, Houston, USA
In the present study, the researchers aimed at characterizing the immune profile, mutational rate, and neoantigen formation of premalignant lesions in patients with Lynch syndrome (LS). The researchers used whole-genome transcriptomic analysis of data from patients and showed that LS polyps have a distinct immune profile and antigen repertoire that opens the door to the implementation of vaccines or immune checkpoint inhibitors for cancer prevention in premalignant lesions.
Immune profiling of premalignant lesions in patients with Lynch syndrome
Eduardo Vilar
Added on: 07-27-2021
[1] https://jamanetwork.com/journals/jamaoncology/fullarticle/2679035[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
