Bioinformatics to design breast cancer therapy
2018
Tabriz University of Medical Sciences, Tabriz, Iran
Triple-negative breast cancer (TNBC) is an important subtype of breast cancer. TNBC may be a cancer testis antigen (CTA)-positive tumor, opening the door for therapy targeting the CTA. In the present study, the researchers used an immunoinformatics approach to design a peptide vaccine to combat TNBC using three peptides in order to stimulate the humoral, cellular and innate immune responses. The vaccine structure was also subjected to the molecular dynamics simulation study for structure refinement. The informatics results verified the immunogenicity and safety profile of the constructed vaccine as well as its capability for stimulating both the cellular and humoral immune responses. The proposed vaccine may be considered for the immunotherapy of TNBC.
In silico design of a triple-negative breast cancer vaccine by targeting cancer testis antigens
Yadollah Omidi
Added on: 07-27-2021
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378095/[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
