Biofabricated multicellular 3D breast cancer model
November 2018
University of Nebraska Medical Center, Omaha, USA
The content of the study is the biofabrication of a multicellular 3D model to improve drug resistance studies in breast cancer. The model is built with hydrogel bioinks combined with human adipose-derived mesenchymal stromal cells and human HER2+ breast cancer cells. Compared to 2D co-culture models, this new model shows higher resistance to doxorubicin treatment. Additionally, different modifications of the 3D bioprinted constructs influence the capacity of drug resistance of the model. Finally, it was possible to increase drug sensitivity through a lysyl oxidase inhibitor. Overall, this 3D model shows several advantages compared to currently available models to understand breast cancer pathology and explore different therapeutic strategies.
3D bioprinting of breast cancer models for drug resistance study
Bin Duan, Vimla Band
Added on: 07-27-2021
[1] https://pubs.acs.org/doi/10.1021/acsbiomaterials.8b01277[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
