Cancer therapies combination assisted by mathematical modeling
2016
Aix Marseille University, Marseille, France(1)
Assistance Publique-Hopitaux Marseille, Marseille, France(2)
Assistance Publique-Hopitaux Marseille, Marseille, France(2)
Combining radiotherapy with immunotherapy may offer a considerable therapeutic impact. In this study, the researchers propose a set of mathematical equations that describe the pharmacodynamics of radiotherapy in combination with two paradigmatic immunotherapies used. The modelling offers an explanation for the reported biphasic relationship between the size of a tumor and its immunogenicity and how synchronizing immunotherapy and radiotherapy can produce synergies. The ability of the model was validated retrospectively by checking data from experimental studies. Such a model could further facilitate decision making about optimal scheduling of immunotherapy with radiotherapy.
Mathematical modeling of cancer immunotherapy and its synergy with radiotherapy
Dominique Barbolosi(1), Xavier Muracciole(2)
Added on: 07-26-2021
[1] https://cancerres.aacrjournals.org/content/76/17/4931.short[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
