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Multiphase and multicellular 3D model of breast cancer metastasis to bone

2018
Max Bergmann Center of Biomaterials, Dresden, Germany
#3D model, #breast cancer, #cancer cells, #hydrogel, #metastasis, #tumor microenvironment, #tumor organoids
The study describes the development of a 3D model based on hydro- and cryogels containing human breast cancer cells and human primary osteoblasts, respectively. The properties of the gels can be tuned to manipulate cell function, which allows the modulation of cellular migration. All these possibilities corroborate the potential of these models to create biomimetic microenvironments to investigate cell-cell and cell-matrix interactions in metastatic processes.
Three-dimensional in vitro hydro- and cryogel-based cell-culture models for the study of breast-cancer metastasis to bone
Laura J Bray

Laura J Bray et al. Cancers 2018 [1]   URL
EURL ECVAM [2]   URL
#668
Added on: 07-22-2021
[1] https://www.mdpi.com/2072-6694/10/9/292[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
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