3D model of hypoxia in tumor microenvironment
2018
University of Nebraska Medical Center, Omaha, USA(1)
University of Nebraska-Lincoln, Lincoln, USA(2)
University of Nebraska-Lincoln, Lincoln, USA(2)
A hydrogel-based 3D model is developed to study hypoxia in epithelial to mesenchymal transition in human breast cancer cells. This model shows the importance of hypoxia as a trigger of epithelial to mesenchymal transition and cancer cell migration. When combining human breast cancer hydrogels with lung mesenchymal cells hydrogels, in hypoxic conditions, the researchers confirmed the activation of invasive behaviour of cancer cells. Also, it was possible to identify a new potential target to block cancer cell invasion with the same model. Overall, this study validates these new hydrogel-based 3D models as tools to study metastasis-related mechanisms.
3D hydrogel breast cancer models for studying the effects of hypoxia on epithelial to mesenchymal transition
Vimla Band(1), Bin Duan(2)
Added on: 07-21-2021
[1] https://www.oncotarget.com/article/25891/[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
