Complex tumor model to test drug effects on cancer-associated cell types
2020
University College London, London, United Kingdom
Simple monolayer in vitro cultures restrict the possibilities of drug testing to specific cell types. In this study, a new model is developed with the inclusion of a stromal compartment to reflect the complex multicellular tumor environments. This new model allowed the researchers to describe the effects of the drug Pazopanib on endothelial cell network and renal cell carcinoma cells, showing that this can be a good model to test drugs whose effects are not limited to cancer cells.
The anti-angiogenic tyrosine kinase inhibitor Pazopanib kills cancer cells and disrupts endothelial networks in biomimetic three-dimensional renal tumouroids
Katerina Stamati
Added on: 07-18-2021
[1] https://journals.sagepub.com/doi/10.1177/2041731420920597[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
