Microfluidic chip system to model breast cancer in 3D environment
2016
Purdue University, West Lafayette, USA(1)
University of Illinois at Urbana−Champaign, Urbana, USA(2)
University of Illinois at Urbana−Champaign, Urbana, USA(2)
A collagen-based 3D model was coupled to a microfluidic system on a chip that allows independent modulation of matrix stiffness and interstitial fluid flow. This model offers a better adaptation of human breast cancer cells based on immunofluorescence analysis. The tuning of the matrix characteristics will allow to investigate the role of extracellular tumor microenvironments.
Modulation of matrix softness and interstitial flow for 3D cell culture using a cell-microenvironment-on-a-chip system
Bumsoo Han(1), Hyunjoon Kong(2)
Added on: 07-15-2021
[1] https://pubs.acs.org/doi/10.1021/acsbiomaterials.6b00379[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
