New multicellular 3D model for metastasis of breast cancer
2016
Weill Cornell Medical College, New York, USA
New model was developed based on hydrogel-encapsulated human breast cancer cells with a central microchannel populated with human aortic smooth muscle cells and human umbilical vein endothelial cells. In this model, the tumor cells induce aberrant vascular cell organization and matrix remodelling to, finally, migrate to the newly formed vessel. This model shows great potential to study metastasis-related mechanisms and drug target discovery.
A novel three-dimensional platform to investigate neoangiogenesis, transendothelial migration, and metastasis of MDAMB-231 breast cancer cells
Jason A Spector
Added on: 07-15-2021
[1] https://journals.lww.com/plasreconsurg/Abstract/2016/09000/A_Novel_Three_Dimensional_Platform_to_Investigate.19.aspx[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
