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Drug test in 3D model shows new insights in cancer stem cell response

2017
Boston University, Boston, USA
#3D model, #cancer stem cells, #cancer therapy
Two chemotherapeutic agents (Paclitaxel and Cisplatin) show differential responses in three different human breast cancer models. The different dynamics in the three different models give key insights into the mechanisms of these drugs and the cancer stem cell responses. Overall, the 3D multicellular model is has a great potential to recreate the different interactions and dynamics in human breast tumor microenvironments in vitro .
Breast cancer spheroids reveal a differential cancer stem cell response to chemotherapeutic treatment
Mark W Grinstaff, Muhammad H Zaman

Daniel S Reynolds et al. Scientific Reports 2017 [1]   URL
EURL ECVAM [2]   URL
#648
Added on: 07-14-2021
[1] https://www.nature.com/articles/s41598-017-10863-4[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
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