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Improved in vitro model of bone metastasis

2019
East China Jiaotong University, Nanchang, China(1)
Tianjin University, Tianjin, China(2)
#3D model, #biomaterials, #cancer cells, #metastasis
Construction of a biomimetic 3D scaffold of PLGA nanofibers incorporating hydroxyapatite to more consistently recapitulate the skeletal microenvironment in vitro during metastasis. In these scaffolds the properties of human breast cancer cells correlate better with the in vivo cell behaviour, confirming the biocompatibility of this model and the suitability of this model as a new platform for 3D cancer cell culture.
Incorporation of hydroxyapatite into nanofibrous PLGA scaffold towards improved breast cancer cell behavior
Quanchao Zhang(1), Yizao Wan(2)

Honglin Luo et al. Materials Chemistry and Physics 2019 [1]   URL
EURL ECVAM [2]   URL
#645
Added on: 07-14-2021
[1] https://www.sciencedirect.com/science/article/abs/pii/S0254058419300264?via%3Dihub[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
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