A novel 3D cancer model to test potential immune therapy in a high-throughput fashion
Company 2018
Corning Incorporated, Kennebunk, USA
New cancer models are needed to efficiently screen for potential therapies, especially the promising autologous immune cells. Immune cell therapy has to be tested for its ability to migrate, invade tumors and kill cancer cells. The regular two-dimensional in vitro models based on a monolayer of cultured cells are too limited. The study establishes a more in-vivo-like model combining a 96-well low-attachment microplate and a 96-well permeable support system with standard human cancer cells to form spheroids. This method allows for the investigation of immune cell homing, immune invasion of tumor spheroids, and spheroid cytotoxicity in a high-throughput fashion.
A novel three-dimensional immune oncology model for high-throughput testing of tumoricidal activity
Ann E. Rossi
Added on: 07-06-2021
[1] https://www.frontiersin.org/articles/10.3389/fimmu.2018.00857/full[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
