Spheroid model of ovarian cancer enables testing of hormone regulation and signaling of metastasis
December 2018
Indian Institute of Science, Bengaluru, India
In vitro spheroid model of ovarian cancer was generated from patients ascites and primary tumor tissues. This model was shown to be regulated by follicle-stimulating hormone (FSH) through Notch signaling. Spheroid formation and cell proliferation was blocked in vitro using FSH and Notch antagonistic antibodies. Thus, Notch and FSH are potential immunotherapeutic targets for ovarian cancer treatment.
Follicle-stimulating hormone is an autocrine regulator of the ovarian cancer metastatic niche through notch signaling
Rajan Dighe, Ramray Bhat
Added on: 07-06-2021
[1] https://academic.oup.com/jes/article/3/2/340/5239847[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
