Novel in vitro pancreatic tumor model recapitulates tumor characteristics and microenvironment
2018
Medical College of Wisconsin, Milwaukee, USA
First report of novel and disease-relevant 3D in-vitro models representing pancreatic tumor, stromal and immune components using primary organoid co-cultures representative of the tumor microenvironment. These models promise to facilitate the study of tumor-stroma and tumor-immune interaction and may be valuable for the assessment of immunotherapeutics such as checkpoint inhibitors.
Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models
Michael A. James
Added on: 07-01-2021
[1] https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4238-4[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
