Novel 3D model of glioblastoma with controllable tumor microenvironment
2018
City University of Hong Kong, Hong Kong, Hong Kong SAR of China(1)
New York University, Brooklyn, USA(2)
New York University, Brooklyn, USA(2)
A novel glioblastoma 3D model is generated and preclinically tested incororating microfluidic angiogenesis, controllable and biomimetic immunosuppressive conditions, immune-vascular and cell-matrix interactions. Reconstituting organotypic tumor angiogenesis models with biomimetic cell heterogeneity and interactions, inflammatory milieu and extracellular matrix mechanics is critical for preclinical anti-angiogenic therapeutic screening and has not been integrated in vitro model until now.
Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis
Raymond H. W. Lam(1), Weiqiang Chen(2)
Added on: 07-01-2021
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059366/[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
