Distinction between healthy and leukemic blood stem cells
2021
European Molecular Biology Laboratory (EMBL), Heidelberg, Germany(1)
The Barcelona Institute of Science and Technology, Barcelona, Spain(2)
The Barcelona Institute of Science and Technology, Barcelona, Spain(2)
By using single-cell multi-OMICS approaches, the researchers could distinguish between leukemic stem cells and healthy hematopoietic stem cells obtained from acute myeloid leukemia (AML) patients. This approach enables the identification of cancer-specific gene expression programs and the characterization of differentiation blocks induced by leukemic mutations.
Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics
Lars M. Steinmetz(1), Lars Velten(2)
Added on: 05-11-2021
[1] https://www.nature.com/articles/s41467-021-21650-1[2] https://www.bionity.com/en/news/1170344/new-single-cell-analysis-of-leucemic-stem-cells.html
