Cells programmed for diagnostics and therapy
December 2020
ETH Zurich, Basel, Switzerland
The biological origins of diseases are often highly complex and individual, while the disease itself is often treated with one or a few drugs. Here genetic cassettes were used in order to modify the properties of human cells for future applications in a way similar to the programming of a computer. These engineered cells could then diagnose or even directly treat pathologically altered cells before they trigger a disease. A possible application would be cancer therapy, where these diagnostic, programmed cells can detect certain biochemical cell structures, classified as "cancer cells", and eliminate them directly.
Multiple alternative promoters and alternative splicing enable universal transcription-based logic computation in mammalian cells
Yaakov Benenson
Added on: 04-30-2021
[1] www.cell.com/cell-reports/fulltext/S2211-1247(20)31426-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124720314261%3Fshowall%3Dtrue[2] https://www.bionity.com/en/news/1170185/cells-as-computers.html
