Human model for neuronal development and disorders
November 2020
Charité-Universitätsmedizin, Berlin, Germany(1)
University of Konstanz, Konstanz, Germany(2)
University of Konstanz, Konstanz, Germany(2)
Disturbances during fetal development lead to congenital malformations (spina bifida, anencephaly) and may contribute to neuropsychiatric disorders like attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorders (ASD) or schizophrenia.
This human embryonic stem cell (hESC)-model is suitable to study the early development of the neuroectodermal layer and later nervous system. It allows the analysis of the highly dynamic and large-scale transcriptome changes which occur during (normal) neurodevelopment. Moreover, by introducing the neurotoxic valproic acid, clinically relevant neurodevelopmental disorder models can be established. Yet little is known about the underlying mechanisms and this model may contribute to study disease mechanisms within a broadly applicable field.
Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation
Nils Blüthgen(1), Marcel Leist(2)
Added on: 04-27-2021
[1] www.academic.oup.com/nar/article/48/22/12577/6007664
